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KMID : 0361420050290040406
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Journal of Korean Academy of Rehabilitation Medicine
2005 Volume.29 No. 4 p.406 ~ p.412
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The Response of the Injured Articular Cartilage of Rabbit Knee after Injection of Autologous Blood
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Kim Soo-A
Kim Eui-Han
Kim Jin-Il
Jang Il
Lee Ji-Soo
Lee Yang-Gyun
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Abstract
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Objective: To evaluate the effects of proliferant by injecting blood into the articular cartilage defect.
Methods: The patella of rabbits were dislocated laterally and 2 mm circular and 2 mm depth full-thickness defect was made in the articular cartilage. We injected 0.2 cc autologous blood to the right defect and normal saline to the left one at 1 week after operation for six times with a 1 week interval. After injection for six weeks, the articular cartilage defect were obtained and stained with H-E and S-100.
Results: The surface of the saline-injected group was easily distinguishable from the surrounding articular cartilage. But the blood-injected group had similar appearance to the surrounding cartilage, with the margin of the defect barely discerptible. Strong S-100 stained immune cartilage cells were observed in the blood-injected group.
Conclusion: The repairing process of the injured articular cartilage using autologous blood was shown to be much better than that of saline-injected group although the observation period was short and the number of animal was small. So we found that autologous blood effectively repaired osteochondral defects.
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KEYWORD
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Articular Cartilage, Proliferant, Dextrose, Blood
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